• Dissection of molecular pathways and regulatory networks underlying sweat gland, hair and mammary gland development and evolution.
• Uncovering the mechanistic basis for functional variation and context specificity of developmental skin enhancers.
• Regeneration of mammalian skin appendages in vitro.
• Discovery and functional modeling of evolutionarily-significant human genetic variants.
Hair and sweat glands in mouse feet
Human eccrine gland
single transcriptomic analysis of developing mouse skin
Genetic basis for the sweaty human ape
Repeated mutation of an Engrailed 1 (EN1) skin enhancer during human evolution drove increased density of sweat glands in human skin
in vivo enhancer screening
cross section of mouse skin infected enhancer reporter virus showing basal-layer specific activity
En1 expression in mouse ventral limb
Mouse mammary gland
Developing skin appendages
Sweat gland openings human digit